Bifunctional chemical probes inducing protein–protein interactions
نویسندگان
چکیده
منابع مشابه
Chemical nucleases as probes for studying DNA-protein interactions.
Over the past fifteen years much research has been devoted to the mode(s) by which the linear DNA macromolecule communicates with cellular proteins in the course of genetic programming, thus determining the patterns of growth and development in living organisms. A plethora of proteins have been shown to interact non-covalently with DNA either as structural elements, exemplified by the histones ...
متن کاملEpigenetic chemical probes.
Epigenetic control of gene expression occurs at two distinctlevels: DNA methylation and histone modification. Over thepast 10 years, the discovery of epigenetic targets has acceleratedto the point where more than 400 domains have beenidentified that are involved in either DNA methylation, themodification of histones (and some nonhistones), or translationof these modifications into changes in ge...
متن کاملRetooling chemical probes
In 2007, scientists from Sirtris Pharmaceuticals along with academic collaborators reported the identification of a series of compounds that activated SIRT1 in vitro and led to beneficial effects in mouse models of type II diabetes (Nature 450, 712–716, 2007). It is widely believed that based at least in part on the discovery of SIRT1 activator compounds, GSK acquired Sirtris for $720 million i...
متن کاملFacile SNP detection using bifunctional, cross-linking oligonucleotide probes
A facile, sensitive method for detecting specific sequences of oligonucleotides was developed. Detection of DNA sequences with single nucleotide discrimination is achieved by combining the selectivity of hybridization with an efficient cross-linking reaction. Readily synthesized bifunctional oligonucleotide probes containing a modified pyrimidine that is capable of forming interstrand cross-lin...
متن کاملBifunctional Supported Catalysts for Fine Chemical Synthesis
............................................................................................................................ iii Chapter 1 ...........................................................................................................................
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2019
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2019.07.003